seminar_Cambridge_Shery Huang

Multiscale Biofabrication Towards System ‘Engineering’ Biology

Presenter: Prof. Yan Yan Shery Huang
Professor of Bioengineering
Funding: ERC (European Research Council)

Context

Medical and technological innovations bring direct health and economic benefits in the near and intermediate terms. But what about the future? Multiscale biofabrication opens new possibilities for:

• Sustainability
• Regenerative medicine
• Personalized treatment

Aim: Multiscale Biofabrication for Engineering System-Level Biology

Future biofabrication should be:

• Eco-friendly
• Imperceptible
• Adaptive/Customized
• In Situ Fabrication

Biofabrication: (Bio)Material Organization

• Spanning cross-length scales
• Utilizing multi-materials
• Integrating living & dynamic components

System & Context Dependent Approach

• Design considerations
• Material & Technique selection

---

1. Microfluidics & Micropatterning

Microvessels on a Chip

---

2. Technology Overview: (Bio)Printing

Printer.HM: Hackable & Multi-functional for Soft Materials

GitHub Repository

3D printing enables explainable machine learning.

Printed Structures:

• Side view
• Top view

---

3. Imperceptible Fibres as Biointerface & Sensing Elements

Biocompatible, Imperceptible Fibres for Cell Sensing

• Impedimetric sensing of cell attachment and alignment

---

Reflections

• The integration of machine learning with 3D printing is opening new frontiers in biofabrication and biomedical engineering.